Comparative Structure Prediction

Table of Contents

• Incorporate Evolutionary Information
• Comparative Structure Prediction API

Incorporate Evolutionary Information

Consensus structures can be predicted by a modified version of the fold() algorithm that takes a set of aligned sequences instead of a single sequence. The energy function consists of the mean energy averaged over the sequences, plus a covariance term that favors pairs with consistent and compensatory mutations and penalizes pairs that cannot be formed by all structures. For details see [12] and [3].

Comparative Structure Prediction API

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