# STOCKHOLM 1.0 #=GF ID Pkinase #=GF AC PF00069.24 #=GF DE Protein kinase domain #=GF PI pkinase; #=GF AU Sonnhammer ELL #=GF SE Unknown #=GF GA 27.00 27.00; #=GF TC 27.00 27.00; #=GF NC 26.90 26.90; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF WK Protein_kinase_domain #=GF RN [1] #=GF RM 1956325 #=GF RT Protein kinase catalytic domain sequence database: #=GF RT identification of conserved features of primary structure and #=GF RT classification of family members. #=GF RA Hanks SK, Quinn AM; #=GF RL Methods Enzymol 1991;200:38-62. #=GF RN [2] #=GF RM 7768349 #=GF RT Protein kinases 6. The eukaryotic protein kinase superfamily: #=GF RT kinase (catalytic) domain structure and classification. #=GF RA Hanks SK, Hunter T; #=GF RL FASEB J 1995;9:576-596. #=GF RN [3] #=GF RM 9020587 #=GF RT The protein kinases of budding yeast: six score and more. #=GF RA Hunter T, Plowman GD; #=GF RL Trends Biochem Sci 1997;22:18-22. #=GF DR INTERPRO; IPR000719; #=GF DR PROSITE; PDOC00100; #=GF DR PROSITE; PDOC00212; #=GF DR PROSITE; PDOC00213; #=GF DR PROSITE; PDOC00629; #=GF DR PROSITE_PROFILE; PS50011; #=GF DR PRINTS; PR00109; #=GF DR SMART; STYKc; #=GF DC Protein kinase; unclassified specificity. #=GF DR SMART; S_TKc; #=GF DC Serine/Threonine protein kinases, catalytic domain #=GF DR SMART; TyrKc; #=GF DC Tyrosine kinase, catalytic domain #=GF DR SCOP; 1apm; sf; #=GF DR HOMSTRAD; kinase; #=GF DR HOMSTRAD; TyrKc; #=GF SQ 38 #=GS CDC15_YEAST/25-272 AC P27636.3 #=GS BYR2_SCHPO/394-658 AC P28829.1 #=GS STE20_YEAST/620-871 AC Q03497.1 #=GS MKK1_YEAST/221-488 AC P32490.1 #=GS STE7_YEAST/191-466 AC P06784.1 #=GS BYR1_SCHPO/66-320 AC P10506.1 #=GS M3K9_HUMAN/144-403 AC P80192.3 #=GS M3K9_HUMAN/144-403 DR PDB; 3DTC A; 144-403; #=GS M3K9_HUMAN/144-403 DR PDB; 4UY9 A; 144-403; #=GS M3K9_HUMAN/144-403 DR PDB; 4UY9 B; 144-403; #=GS F7CJC0_CALJA/134-393 AC F7CJC0.1 #=GS KPRO_MAIZE/534-810 AC P17801.2 #=GS TTK_HUMAN/525-791 AC P33981.2 #=GS TTK_HUMAN/525-791 DR PDB; 5EH0 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4BI2 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4JT3 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 2X9E A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4O6L A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4D2S A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5EI6 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3H9F A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3WYY A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 2ZMC A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4C4J A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4CV8 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3WZJ A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5AP6 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3WZK A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3WYX A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5AP5 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4BHZ A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3HMO A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5AP3 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3HMP A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4JS8 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4BI0 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3DBQ A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3W1F A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4C4I A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3CEK A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3VQU A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4O6L B; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5EI8 A; 525-753; #=GS TTK_HUMAN/525-791 DR PDB; 4CVA A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4BI1 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 2ZMD A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5AP4 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5AP7 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5EHY A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5EHL A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4C4E A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4C4H A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4C4G A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5AP1 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4CV9 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3GFW A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 3HMN A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5AP0 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4C4F A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5AP2 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5LJJ A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5EI2 A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 4ZEG A; 525-791; #=GS TTK_HUMAN/525-791 DR PDB; 5EHO A; 525-791; #=GS WEE1_HUMAN/299-569 AC P30291.2 #=GS WEE1_HUMAN/299-569 DR PDB; 2IN6 A; 299-569; #=GS WEE1_HUMAN/299-569 DR PDB; 3BI6 A; 299-569; #=GS WEE1_HUMAN/299-569 DR PDB; 1X8B A; 299-569; #=GS WEE1_HUMAN/299-569 DR PDB; 3CR0 A; 299-569; #=GS WEE1_HUMAN/299-569 DR PDB; 2IO6 A; 299-569; #=GS WEE1_HUMAN/299-569 DR PDB; 3CQE A; 299-569; #=GS WEE1_HUMAN/299-569 DR PDB; 2Z2W A; 299-569; #=GS WEE1_HUMAN/299-569 DR PDB; 3BIZ A; 299-569; #=GS CSK21_CHICK/39-324 AC P21868.1 #=GS BUR1_YEAST/60-366 AC P23293.1 #=GS CTK1_YEAST/183-469 AC Q03957.1 #=GS KIN28_YEAST/7-290 AC P06242.1 #=GS I1MG96_SOYBN/4-287 AC I1MG96.1 #=GS CDKL1_HUMAN/4-287 AC Q00532.5 #=GS CDKL1_HUMAN/4-287 DR PDB; 4AGU B; 4-287; #=GS CDKL1_HUMAN/4-287 DR PDB; 4AGU C; 4-287; #=GS CDKL1_HUMAN/4-287 DR PDB; 4AGU A; 4-287; #=GS MAK_RAT/4-284 AC P20793.2 #=GS GSK3A_RAT/119-403 AC P18265.1 #=GS MK04_HUMAN/20-312 AC P31152.2 #=GS PIM1_HUMAN/129-381 AC P11309.3 #=GS PIM1_HUMAN/129-381 DR PDB; 3JXW A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YXU A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 5IPJ A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4MED A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4ALW A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3BWF A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4LMU A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3UMW A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3CXW A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 5KZI A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4JX3 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3MA3 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 5DGZ A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YXV A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3R01 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2XJ2 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4K18 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2J2I B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4IAA A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4RC2 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3VBQ A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4N6Z A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YWV A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2BZI B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4ENY A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4GW8 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3DCV A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2O3P A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4AS0 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4MTA A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 5DHJ A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3C4E B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YXU D; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3JYA A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3UMX A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4ENX A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4MBL A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4BZN A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2XJ0 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2BIL B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3VBW A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2OI4 X; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3CY3 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2OBJ A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YI4 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3C4E D; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2C3I B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2XJ1 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3R02 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2BIK B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 5DWR A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YHS A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3WE8 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 5C1Q B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4XHK B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YXS A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2BZK B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4RPV A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3C4E A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3JY0 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4N70 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3R00 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2BZJ A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1XR1 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 5EOL A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4DTK A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YXX A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4XH6 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1XQZ A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2XIX A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3QF9 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2XIY A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YXU B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4RC3 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4N6Y A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YXT A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2XIZ A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4MBI A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3CY2 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4ALV A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4A7C A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3VBT A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3BGP A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4WRS A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2BZH B; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3BGZ A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3BGQ A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3R04 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2O64 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YI3 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3JPV A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3VBV A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4WT6 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4TY1 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 5IIS A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3UIX A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4I41 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1XWS A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4WSY A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4BZO A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3VBX A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4JX7 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 5DIA A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4LM5 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4LL5 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4RC4 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3VBY A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3T9I A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4RBL A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 1YXU C; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4ALU A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3VC4 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2O65 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4K1B A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3F2A A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 4K0Y A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3C4E C; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 2O63 A; 38-290; #=GS PIM1_HUMAN/129-381 DR PDB; 3A99 A; 38-290; #=GS PSK1_YEAST/1096-1354 AC P31374.2 #=GS CDC5_YEAST/82-337 AC P32562.1 #=GS AKT1_HUMAN/150-408 AC P31749.2 #=GS AKT1_HUMAN/150-408 DR PDB; 4EKK A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 4EKK B; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3OCB B; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 4EJN A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3QKM A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3OCB A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3MV5 A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3MVH A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 4GV1 A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3O96 A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3OW4 B; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 4EKL A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 5KCV A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3CQW A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3CQU A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3QKK A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3OW4 A; 150-408; #=GS AKT1_HUMAN/150-408 DR PDB; 3QKL A; 150-408; #=GS ARBK1_BOVIN/191-453 AC P21146.1 #=GS ARBK1_BOVIN/191-453 DR PDB; 3UZT A; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 3UZS A; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 1YM7 B; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 3PVU A; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 1OMW A; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 1YM7 A; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 3PSC A; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 1YM7 D; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 3PVW A; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 5HE3 A; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 5HE2 A; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 1YM7 C; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 5HE0 A; 191-453; #=GS ARBK1_BOVIN/191-453 DR PDB; 2BCJ A; 191-453; #=GS KIN82_YEAST/324-602 AC P25341.3 #=GS PKD1_DICDI/334-589 AC P34100.2 #=GS KGP1_DROME/457-717 AC Q03042.2 #=GS RAD53_YEAST/198-466 AC P22216.1 #=GS RAD53_YEAST/198-466 DR PDB; 4PDS B; 199-466; #=GS RAD53_YEAST/198-466 DR PDB; 4PDP A; 199-466; #=GS RAD53_YEAST/198-466 DR PDB; 4PDS A; 199-466; #=GS RAD53_YEAST/198-466 DR PDB; 4PDP B; 199-466; #=GS CDR1_SCHPO/12-258 AC P07334.3 #=GS KS6A1_MOUSE/407-664 AC P18653.1 #=GS PHKG2_RAT/24-291 AC P31325.1 #=GS KCC4_MOUSE/42-296 AC P08414.2 #=GS MYLK_CHICK/1453-1708 AC P11799.2 #=GS CDPK_SOYBN/34-292 AC P28583.1 #=GS Q8I534_PLAF7/111-364 AC Q8I534.1 #=GS CHK1_SCHPO/10-272 AC P34208.2 #=GS FUSED_DROME/4-254 AC P23647.2 CDC15_YEAST/25-272 YHLKQVIGRGSYGVV..YKAINKHTDQVVAIKEVVYENDEELND........IMAEISLLKNLN...HNNIVKYHGFIRK.............SYELY..ILLEYCANGS....LRRLIS.......RSSTGLSEN.......ESK.TYVTQTLLGLKYLH.GEG...VIHRDIKAANILLS............ADN.......TVKLADFGVSTIVNSS.....................ALTLAGTLNWMAPEIL..........GN...RGA.STLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVEND.........................TYYPPSSF....................................SEPLKDFLSKCFVKNMYKRPT.....ADQLLKHVWI #=GR CDC15_YEAST/25-272 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR CDC15_YEAST/25-272 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... BYR2_SCHPO/394-658 WIRGALIGSGSFGQV..YLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELS...HEHIVQYLGSNLN.............SDHLN..IFLEYVPGGS....VAGLLTM....YG...S.FEET.......LVK.NFIKQTLKGLEYLH.SRG...IVHRDIKGANILVD.N..........KGK........IKISDFGISKKLELNSTSTK............TGGARPSFQGSSFWMAPEVV..........KQ...TMH.TEKTDIWSLGCLVIEMLTSKHPYP..........NCDQ..MQAIFRI............GENILPEFPSNI....................................SSSAIDFLEKTFAIDCNLRPT.....ASELLSHPFV #=GR BYR2_SCHPO/394-658 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR BYR2_SCHPO/394-658 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... STE20_YEAST/620-871 YANLVKIGQGASGGV..YTAYEIGTNVSVAIKQMNLEKQPKKEL........IINEILVMKGSK...HPNIVNFIDSYVL.............KGDLW..VIMEYMEGGS....LTDVV........THCI.LTEG.......QIG.AVCRETLSGLEFLH.SKG...VLHRDIKSDNILLS.M..........EGD........IKLTDFGFCAQINELNL..................KRTTMVGTPYWMAPEVV..........SR...KEY.GPKVDIWSLGIMIIEMIEGEPPYL............NETPLRALYLIAT..........NGTPKLKEPENL....................................SSSLKKFLDWCLCVEPEDRAS.....ATELLHDEYI #=GR STE20_YEAST/620-871 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR STE20_YEAST/620-871 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... MKK1_YEAST/221-488 IETLGILGEGAGGSV..SKCKLKNGSKIFALKVINTLNTDPEYQ......KQIFRELQFNRSFQ...SEYIVRYYGMFTDD...........ENSSIY..IAMEYMGGRSLDAIYKNLLE.......RGGR.ISEK.......VLG.KIAEAVLRGLSYLH.EKK...VIHRDIKPQNILLN.E..........NGQ........VKLCDFGVSGEAVNSL....................ATTFTGTSFYMAPERI..........QG...QPY.SVTSDVWSLGLTILEVANGKFPCS....SEKMAANIAP..FELLMWILT.........FTPELKDEPESNII..................................WSPSFKSFIDYCLKKDSRERPS.....PRQMINHPWI #=GR MKK1_YEAST/221-488 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR MKK1_YEAST/221-488 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... STE7_YEAST/191-466 LVQLGKIGAGNSGTV..VKALHVPDSKIVAKKTIPVEQNNSTII......NQLVRELSIVKNVK..PHENIITFYGAYYNQ..........HINNEII..ILMEYSDCGS....LDKILSVYK.RFVQRGT.VSSKKTWFNELTIS.KIAYGVLNGLDHLYRQYK...IIHRDIKPSNVLIN.S..........KGQ........IKLCDFGVSKKLINSI....................ADTFVGTSTYMSPERI..........QG...NVY.SIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQ..........R..........IVNEPSPRLPKDR.................................IYSKEMTDFVNRCCIKNERERSS.....IHELLHHDLI #=GR STE7_YEAST/191-466 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR STE7_YEAST/191-466 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... BYR1_SCHPO/66-320 LEVVRHLGEGNGGAV..SLVK..HRNIFMARKTVYVGSDSKLQ.......KQILRELGVLHHCR...SPYIVGFYGAFQY.............KNNIS..LCMEYMDCGS....LDAILR.......EGGP.IPLD.......ILG.KIINSMVKGLIYLYNVLH...IIHRDLKPSNVVVN.S..........RGE........IKLCDFGVSGELVNSV....................AQTFVGTSTYMSPERI..........RG...GKY.TVKSDIWSLGISIIELATQELPWS........FSNIDD..SIGILDLLH.........CIVQEEPPRLPSS...................................FPEDLRLFVDACLHKDPTLRAS.....PQQLCAMPYF #=GR BYR1_SCHPO/66-320 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR BYR1_SCHPO/66-320 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... M3K9_HUMAN/144-403 LTLEEIIGIGGFGKV..YRAF..WIGDEVAVKAARHDPDEDISQT....IENVRQEAKLFAMLK...HPNIIALRGVCLK.............EPNLC..LVMEFARGGP....LNRVLSG....KR.....IPPD.......ILV.NWAVQIARGMNYLH.DEAIVPIIHRDLKSSNILILQ...........KVENGDLSNKILKITDFGLAREWHRTT....................KMSAAGTYAWMAPEVI..........RA...SMF.SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMN.......................KLALPIPSTC....................................PEPFAKLMEDCWNPDPHSRPS.....FTNILDQ..L #=GR M3K9_HUMAN/144-403 SS EEEEEEEEECSSEEE..EEEE..ETTEEEEEEEE---TTS-HHHH....HHHHHHHHHHHTT--...-TTB--EEEEE-S.............TT--E..EEEE--TTEE....HHHHHHH....S-.....--HH.......HHH.HHHHHHHHHHHHHH.HTSSS----S--SGGGEEESS...........--GGG--SS--EEE-----SGGG---C....................CC--SSGGGGS-HHHH..........HH...---.SHHHHHHHHHHHHHHHHH---TTTTS-HHHHHHHHHTT.......................-------TTS....................................-TTHHHHHHHHT-SSGGGS--.....HHHHHHH..H #=GR M3K9_HUMAN/144-403 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR M3K9_HUMAN/144-403 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... F7CJC0_CALJA/134-393 VMLSTRIGSGSFGTV..YKGK...WHGDVAVKILKVVDPTPEQF......QAFRNEVAVLRKTR...HVNILLFMGYMT..............KDNLA..IVTQWCEGSS....LYKHLH......VQETK.FQMF.......QLI.DIARQTAQGMDYLH.AKN...IIHRDMKSNNIFLH............EGL.......TVKIGDFGLATVKSRWSGS................QQVEQPTGSVLWMAPEVI..........RMQDNNPF.SFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGR.......................GYASPDLSKLYK................................NCPKAMKRLVADCVKKVKEERPL.....FPQILSSIEL #=GR F7CJC0_CALJA/134-393 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. KPRO_MAIZE/534-810 RKFKVELGRGESGTV..YKGV.LEDDRHVAVKKLENVRQGK.........EVFQAELSVIGRIN...HMNLVRIWGFCSE.............GSHRL..LVSEYVENGS....LANIL.............FSEGGNILLDWEGRFNIALGVAKGLAYLH.HECLEWVIHCDVKPENILLD............QAF.......EPKITDFGLVKLLNRGGST................QNVSHVRGTLGYIAPEWV..........SS...LPI.TAKVDVYSYGVVLLELLTGTRVSELVGGTDEVHSMLRKLVRMLSAKLEGEEQSWIDGYLDSKLNRPVNYVQ....................................ARTLIKLAVSCLEEDRSKRPT.....MEHAVQ.... #=GR KPRO_MAIZE/534-810 pAS ............................................................................................................................................................................*....................................*................................................................................................................................................................................................................. TTK_HUMAN/525-791 YSILKQIGSGGSSKV..FQVLN.EKKQIYAIKYVNLEEADNQTL......DSYRNEIAYLNKLQQ.HSDKIIRLYDYEIT.............DQYIY..MVMECGNID.....LNSWLK.......KKKS.IDPW.......ERK.SYWKNMLEAVHTIH.QHG...IVHSDLKPANFLIV............DGM........LKLIDFGIANQMQPDTTS................VVKDSQVGTVNYMPPEAIKDMSSSRENGKS...KSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID.................................PNHEI.........................EFPDIPEKDLQDVLKCCLKRDPKQRIS.....IPELLAHPYV #=GR TTK_HUMAN/525-791 SS EEEEEEEEEESSEEE..EEEEE.TTSBEEEEEEEECTT--HHHH......HHHHHHHHHHHHHTT.T-TTB--EEEEEE-.............SSEEE..EEEE--SEE.....HHHHHH.......HCSS.--HH.......HHH.HHHHHHHHHHHHHH.HTT...---SS--GGGEEEE............TTE........EEE-S-SSSTT-EE--SS................----TTTSTSTT--HHHHHTTT--------...----SHHHHHHHHHHHHHHHHHSS-TTTT--SHHHHHHHHHS.................................TTS--.........................-----S-HHHHHHHHHHT-SSTTTS--.....HHHHTTSHHH #=GR TTK_HUMAN/525-791 pAS ............................................................................................................................................................................*....................................*................................................................................................................................................................................................................. WEE1_HUMAN/299-569 FHELEKIGSGEFGSV..FKCVKRLDGCIYAIKRSKKPLAGSVDE......QNALREVYAHAVLG..QHSHVVRYFSAWAE.............DDHML..IQNEYCNGGS....LADAISE....NYRIMSYFKEA.......ELK.DLLLQVGRGLRYIH.SMS...LVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISS......................PQVEEGDSRFLANEVL..........QE...NYTHLPKADIFALALTVVCA.AGAEPLP...RNGDQWHEIRQGRLPRIPQVL...........................................................SQEFTELLKVMIHPDPERRPS.....AMALVKHSVL #=GR WEE1_HUMAN/299-569 SS EEEEEEEEEESSEEE..EEEEETTTTEEEEEEEEE---TTSHHH......HHHHHHHHHHHHS-..S-TTB--EEEEEEE.............TTEEE..EEEE--TT-B....HHHHHHH....HHHHT----HH.......HHH.HHHHHHHHHHHHHH.HTT...EE-S--SGGGEEEE----------------------EEEE--GTT-EETT-......................SS-----GGG--HHHH..........TT...--TTTHHHHHHHHHHHHHHH.TT-----...SSCHHHHHHHTT-----SS--...........................................................-HHHHHHHHHHT-SSGGGS--.....HHHHHT-TTH #=GR WEE1_HUMAN/299-569 pAS ............................................................................................................................................................................*....................................*................................................................................................................................................................................................................. CSK21_CHICK/39-324 YQLVRKLGRGKYSEV..FEAINITNNEKVVVKILKPVKKKKIKR...........EIKILENLR..GGPNIITLADIVKD.............PVSRTPALVFEHVNNTD....FKQLYQ..........T.LTDY.......DIR.FYMYEILKALDYCH.SMG...IMHRDVKPHNVMIDHE..........HRK........LRLIDWGLAEFYHPGQE...................YNVRVASRYFKGPELL.........VDY...QMY.DYSLDMWSLGCMLASMIFRKEPFFHGHD......NYDQ..LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE...............RFVHSENQHLVSPEALDFLDKLLRYDHQSRLT.....AREAMEHPYF #=GR CSK21_CHICK/39-324 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR CSK21_CHICK/39-324 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... BUR1_YEAST/60-366 YREDEKLGQGTFGEV..YKGIHLETQRQVAMKKIIVSVEKDLFP......ITAQREITILKRLN...HKNIIKLIEMVYDHSPDITNAASSNLHKSFY..MILPYMVADLSGVLHNPRIN............LEMC.......DIK.NMMLQILEGLNYIH.CAK...FMHRDIKTANILID.H..........NGV........LKLADFGLARLYYGCPPNLKYPG......GAGSGAKYTSVVVTRWYRAPELV.........LGD...KQY.TTAVDIWGVGCVFAEFFEKKPILQ...GKT....DIDQ..GHVIFKLLG.........TPTEEDWAVARYLPGAELTTTNYK..............PTLRERFGKYLSETGLDFLGQLLALDPYKRLT.....AMSAKHHPWF #=GR BUR1_YEAST/60-366 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR BUR1_YEAST/60-366 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... CTK1_YEAST/183-469 YLRIMQVGEGTYGKV..YKAKNTNTEKLVALKKLRLQGEREGFP......ITSIREIKLLQSFD...HPNVSTIKEIMVE............SQKTVY..MIFEYADNDLSGLLLNKEVQ............ISHS.......QCK.HLFKQLLLGMEYLH.DNK...ILHRDVKGSNILID.N..........QGN........LKITDFGLARKMNSRAD...................YTNRVITLWYRPPELL.........LGT...TNY.GTEVDMWGCGCLLVELFNKTAIFQ...GSN....ELEQ..IESIFKIMG.........TPTINSWPTLYDMPWFFMIMPQQTTK.........YVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFS.....ATEALQSDYF #=GR CTK1_YEAST/183-469 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR CTK1_YEAST/183-469 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... KIN28_YEAST/7-290 YTKEKKVGEGTYAVV..YLGCQHSTGRKIAIKEIKTSEFKDGLD......MSAIREVKYLQEMQ...HPNVIELIDIFMA.............YDNLN..LVLEFLP........TDLEVVI...KDKSIL.FTPA.......DIK.AWMLMTLRGVYHCH.RNF...ILHRDLKPNNLLFS.P..........DGQ........IKVADFGLARAIPAPHE..................ILTSNVVTRWYRAPELL.........FGA...KHY.TSAIDIWSVGVIFAELMLRIPYLP...GQN....DVDQ..MEVTFRALG.........TPTDRDWPEVSSFMTYNKLQIYPPP............SRDELRKRFIAASEYALDFMCGMLTMNPQKRWT.....AVQCLESDYF #=GR KIN28_YEAST/7-290 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR KIN28_YEAST/7-290 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... I1MG96_SOYBN/4-287 YEKVEKIGEGTYGVV..YKARDRVTNETIALKKIRLEQEDEGVP......STAIREISLLKEMQ...HRNIVRLQDVVHS.............EKRLY..LVFEYLD........LDLKKHM..DSSPEFV.KDPR.......QVK.MFLYQILCGIAYCH.SHR...VLHRDLKPQNLLIDRR..........TNS........LKLADFGLARAFGIPVR..................TFTHEVVTLWYRAPEIL.........LGS...RHY.STPVDVWSVGCIFAEMVNRRPLFP...GDS....EIDE..LFKIFRILG.........TPNEDTWPGVTSLPDFKSTFPKWP..............SKDLANVVPNLDAAGLNLLSSMLCLDPSKRIT.....ARSAVEHEYF #=GR I1MG96_SOYBN/4-287 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. CDKL1_HUMAN/4-287 YEKIGKIGEGSYGVV..FKCRNRDTGQIVAIKKFLESEDDPVIK......KIALREIRMLKQLK...HPNLVNLLEVFRR.............KRRLH..LVFEYCDHTV....LHELDRYQ...RG.....VPEH.......LVK.SITWQTLQAVNFCH.KHN...CIHRDVKPENILIT.K..........HSV........IKLCDFGFARLLAGPSD..................YYTDYVATRWYRSPELL.........VGD...TQY.GPPVDVWAIGCVFAELLSGVPLWP...GKS....DVDQ..LYLIRKTLG..........D..........LIPRHQQVFSTNQYFSGV.KIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLT.....CEQLLHHPYF #=GR CDKL1_HUMAN/4-287 SS EEEEEEEEE-SSEEE..EEEEETTT--EEEEEEE---SS-HHHH......HHHHHHHHHHHH--...-TTB--EEEEEEE.............TTEEE..EEEE--SEEH....HHHHHHTS...S-.....--HH.......HHH.HHHHHHHHHHHHHH.HTT...EE----SGGGEEE-.T..........TS-........EEE---TT-EE------..................--------GGG--HHHH.........TT-...S--.-THHHHHHHHHHHHHHHHSS-S--...-SS....HHHH..HHHHHHHH-..........S..........--HHHHHHHHT-GGGTT-.-----SS---HHHH-TTS-HHHHHHHHHH--SSTTTS--.....HHHHTTSGGG #=GR CDKL1_HUMAN/4-287 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR CDKL1_HUMAN/4-287 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... MAK_RAT/4-284 YTTMRQLGDGTYGSV..LMGKSNESGELVAIKRMKRKFYSWDECMN..LR.....EVKSLKKLN...HANVIKLKEVIRE.............NDHLY..FIFEYMK........ENLYQLM...KDRNKL.FPES.......VIR.NIMYQILQGLAFIH.KHG...FFHRDMKPENLLCM.G..........PEL........VKIADFGLARELRSQPP...................YTDYVSTRWYRAPEVL.........LRS...SVY.SSPIDVWAVGSIMAELYTFRPLFP...GTS....EVDE..IFKICQVLG.........TPKKSDWPEGYQLASSMNFRFPQC.............IPINLKTLIPNASSEAIQLMTEMLNWDPKKRPT.....ASQALKHPYF #=GR MAK_RAT/4-284 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR MAK_RAT/4-284 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... GSK3A_RAT/119-403 YTDIKVIGNGSFGVV..YQARLAETRELVAIKKVLQDKRFKNR............ELQIMRKLD...HCNIVRLRYFFYSSG.........EKKDELYLNLVLEYVP........ETVYRVARHFTKAKLI.IPII.......YVK.VYMYQLFRSLAYIH.SQG...VCHRDIKPQNLLVDPD..........TAV........LKLCDFGSAKQLVRGEP...................NVSYICSRYYRAPELI.........FGA...TDY.TSSIDVWSAGCVLAELLLGQPIFP...GDS....GVDQ..LVEIIKVLG..........T.....PTREQIREMNPNYTEFKFPQ........IKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLS.....PLEACAHSFF #=GR GSK3A_RAT/119-403 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR GSK3A_RAT/119-403 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... MK04_HUMAN/20-312 FVDFQPLGFGVNGLV..LSAVDSRACRKVAVKKIALSDARSMKH........ALREIKIIRRLD...HDNIVKVYEVLGPKGTDL..QGELFKFSVAY..IVQEYMETD.....LARLLEQ....GT.....LAEE.......HAK.LFMYQLLRGLKYIH.SAN...VLHRDLKPANIFISTE..........DLV........LKIGDFGLARIVDQHYSHK...............GYLSEGLVTKWYRSPRLL.........LSP...NNY.TKAIDMWAAGCILAEMLTGRMLFA..........GAHE..LEQMQLILE..........T..........IPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLT.....AEMGLQHPYM #=GR MK04_HUMAN/20-312 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR MK04_HUMAN/20-312 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... PIM1_HUMAN/129-381 YQVGPLLGSGGFGSV..YSGIRVSDNLPVAIKHVEKDRISDWGELP..NGTRVPMEVVLLKKVSS.GFSGVIRLLDWFER.............PDSFV..LILERPEPVQ...DLFDFIT.......ERGA.LQEE.......LAR.SFFWQVLEAVRHCH.NCG...VLHRDIKDENILIDLN..........RGE........LKLIDFGSGALLKDTV....................YTDFDGTRVYSPPEWI..........RY...HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRV...................................................................SSECQHLIRWCLALRPSDRPT.....FEEIQNHPWM #=GR PIM1_HUMAN/129-381 SS EEEEEEEEEETTEEE..EEEEETTTTEEEEEEEEEGGG-SSEEEET..TSEEEEHHHHHHHHHHS.SSTTB--EEEEEEE.............SSEEE..EEEE--SSEE...EHHHHHH.......HHSS.--HH.......HHH.HHHHHHHHHHHHHH.HTT...EE-S--SGGGEEEETT..........TTE........EEE--GTT-EE--SS-....................B----S-GGGS-HHHH..........HH...S-B-HHHHHHHHHHHHHHHHHHSS-S-SSHHHHHHT----SS--...................................................................-HHHHHHHHHHT-SSGGGS--.....HHHHHTSGGG #=GR PIM1_HUMAN/129-381 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR PIM1_HUMAN/129-381 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... PSK1_YEAST/1096-1354 FVSLQKMGEGAYGKV..NLCIHKKNRYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMATLNKKPHENILRLLDFFED.............DDYYY...IETPVHGETGCIDLFDLIE.......FKTN.MTEF.......EAK.LIFKQVVAGIKHLH.DQG...IVHRDIKDENVIVD.S..........KGF........VKIIDFGSAAYVKSGP....................FDVFVGTIDYAAPEVL..........GG...NPYEGQPQDIWAIGILLYTVVFKENPFY..........NIDE..IL.................EGDLKFNNAEEV....................................SEDCIELIKSILNRCVPKRPT.....IDDINNDKWL #=GR PSK1_YEAST/1096-1354 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR PSK1_YEAST/1096-1354 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... CDC5_YEAST/82-337 YHRGHFLGEGGFARC..FQIKD.DSGEIFAAKTVAKASIKSEKT.....RKKLLSEIQIHKSMS...HPNIVQFIDCFED.............DSNVY..ILLEICPNGS....LMELLK.......RRKV.LTEP.......EVR.FFTTQICGAIKYMH.SRR...VIHRDLKLGNIFFD............SNY.......NLKIGDFGLAAVLANESE..................RKYTICGTPNYIAPEVLM........GKH...SGH.SFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCR.......................DFSFPRDKPI....................................SDEGKILIRDILSLDPIERPS.....LTEIMDYVWF #=GR CDC5_YEAST/82-337 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR CDC5_YEAST/82-337 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... AKT1_HUMAN/150-408 FEYLKLLGKGTFGKV..ILVKEKATGRYYAMKILKKEVIVAKDE.....VAHTLTENRVLQNSR...HPFLTALKYSFQT.............HDRLC..FVMEYANGGE....LFFHLS.......RERV.FSED.......RAR.FYGAEIVSALDYLHSEKN...VVYRDLKLENLMLD.K..........DGH........IKITDFGLCKEGIKDGA..................TMKTFCGTPEYLAPEVL..........ED...NDY.GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME.........................EIRFPRTL....................................GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF #=GR AKT1_HUMAN/150-408 SS EEEEEEEEEETTEEE..EEEEETTT--EEEEEEEEHHHHHHTT-.....HHHHHHHHHHHHCSS...-TTB--EEEEEEE.............SSEEE..EEEE--TTEB....HHHHHH.......HHSS.--HH.......HHH.HHHHHHHHHHHHHHHTTT...EB----SGGGEEE-.T..........TS-........EEE---TTSBCS--TT-..................-B--CEE-GGGS-HHHH..........TT...S-B.-TTHHHHHHHHHHHHHHHSS-SS--SSHHHHHHHHHHS.........................-----TTS....................................-HHHHHHHHHHT-SSTTTSTT-STTTHHHHHTSGGG #=GR AKT1_HUMAN/150-408 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR AKT1_HUMAN/150-408 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... ARBK1_BOVIN/191-453 FSVHRIIGRGGFGEV..YGCRKADTGKMYAMKCLDKKRIKMKQG.....ETLALNERIMLSLVSTGDCPFIVCMSYAFHT.............PDKLS..FILDLMNGGD....LHYHLS.......QHGV.FSEA.......DMR.FYAAEIILGLEHMH.NRF...VVYRDLKPANILLD.E..........HGH........VRISDLGLACDFSKKK....................PHASVGTHGYMAPEVL.........QKG...VAY.DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT......................LTMAVELPDSF....................................SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF #=GR ARBK1_BOVIN/191-453 SS EEEEEEEEEESSEEE..EEEEETTT--EEEEEEEEHHHHHHHTT.....HHHHHHHHHHHHHHSSS--TTB--EEEEEEE.............SSEEE..EEEE--TS-B....HHHHHH.......HH-S.--HH.......HHH.HHHHHHHHHHHHHH.HTT...EE----SGGGEEE-.T..........TS-........EEE--GTT-EE-SSS-....................--S--S-TTS--HHHH.........STT...---.STHHHHHHHHHHHHHHHHSS-TT-SSTSS-HHHHHHHH......................HH------TTS....................................-HHHHHHHHHHT-SSSTTSTTTSSSTHHHHHTSGGG #=GR ARBK1_BOVIN/191-453 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR ARBK1_BOVIN/191-453 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... KIN82_YEAST/324-602 FEKIRLLGQGDVGKV..YLVRERDTNQIFALKVLNKHEMIKRKK.....IKRVLTEQEILATSD...HPFIVTLYHSFQT.............KDYLY..LCMEYCMGGE....FFRALQ......TRKSKCIAEE.......DAK.FYASEVVAALEYLH.LLG...FIYRDLKPENILLH.Q..........SGH........VMLSDFDLSIQATGSKKPTMKDSTYLDTKICSDGFRTNSFVGTEEYLAPEVI..........RG...NGH.TAAVDWWTLGILIYEMLFGCTPFKGDNSNETFSNILTK.......................DVKFPHDKEV....................................SKNCKDLIKKLLNKNEAKRLGSK.SGAADIKRHPFF #=GR KIN82_YEAST/324-602 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR KIN82_YEAST/324-602 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... PKD1_DICDI/334-589 FNFYGSLGSGSFGTA..KLCRHRGSGLFFCSKTLRRETIVHEKH.....KEHVNNEINIMLNIS...HPYIVKTYSTFNT.............PTKIH..FIMEYAGKKD....LFHHLR.......ANKC.FTEQ.......TTK.LIVAEIVLAIEYLH.AEN...IIYRDLKPENILID.E..........KGH........IKLTDFGFSKKTVGGKN...................TSSVCGTFDYMAPEIL.........NSS...NGH.GKPVDWWALGVVVYELVTGKLPFSNSKESLLNRKADFQLIFQNSYL.............................................................SDEIKDFIFQLLSVDPSKRLGT..FDSCSIRNHKWF #=GR PKD1_DICDI/334-589 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR PKD1_DICDI/334-589 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... KGP1_DROME/457-717 LEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQ.....EEHIFSERHIMLSSR...SPFICRLYRTFRD.............EKYVY..MLLEACMGGE....IWTMLR.......DRGS.FEDN.......AAQ.FIIGCVLQAFEYLH.ARG...IIYRDLKPENLMLD.E..........RGY........VKIVDFGFAKQIGTSSK...................TWTFCGTPEYVAPEII..........LN...KGH.DRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKG.......................IDMIAFPKHI....................................SRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWF #=GR KGP1_DROME/457-717 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR KGP1_DROME/457-717 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... RAD53_YEAST/198-466 SIIDEVVGQGAFATV..KKAIERTTGKTFAVKIISKRKVIGNMD.......GVTRELEVLQKLN...HPRIVRLKGFYED.............TESYY..MVMEFVSGGD....LMDFVA.......AHGA.VGED.......AGR.EISRQILTAIKYIH.SMG...ISHRDLKPDNILIE............QDDP.....VLVKITDFGLAKVQGNGSF...................MKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEY.SSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFR..........I...............................................SEEARDFIDSLLQVDPNNRST.....AAKALNHPWI #=GR RAD53_YEAST/198-466 SS XEES--S------EE..EEEEETTT--EEEEEEE-S--------.......SHCCHHHHHCH--...-TTB--EEEEEE-.............---EE..EEEE--TT-B....HHHHHH.......HH-S.--HH.......HHH.HHHHHHHHHHHHHH.HTT...EE-S--SCCCEEEE............ETTT.....TEEEE---TT-EE------...................-------GGG--GGGC----------------TT.HHHHHHHHHHHHHHHHHHSS-SS--SSCCHHHHHHHTT---HHHHHHTT..........-...............................................-HHHHHHHHHHS-SSGGGS--.....HHHHHTSCCC #=GR RAD53_YEAST/198-466 AS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... #=GR RAD53_YEAST/198-466 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. CDR1_SCHPO/12-258 WRLGKTLGTGSTSCV..RLAKHAKTGDLAAIKIIPIR............YASIGMEILMMRLLR...HPNILRLYDVWTD.............HQHMY..LALEYVPDGE....LFHYIR.......KHGP.LSER.......EAA.HYLSQILDAVAHCH.RFR...FRHRDLKLENILIKVN..........EQQ........IKIADFGMATVEPNDSC...................LENYCGSLHYLAPEIV..........SH...KPYRGAPADVWSCGVILYSLLSNKLPFGGQNTDVIYNKIRHG.........................AYDLPSSI....................................SSAAQDLLHRMLDVNPSTRIT.....IPEVFSHPFL #=GR CDR1_SCHPO/12-258 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR CDR1_SCHPO/12-258 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... KS6A1_MOUSE/407-664 YVVKETIGVGSYSVC..KRCVHKATNMEYAVKVIDKSKRDPSE............EIEILLRYG..QHPNIITLKDVYDD.............GKHVY..LVTELMRGGE....LLDKIL.......RQKF.FSER.......EAS.FVLHTISKTVEYLH.SQG...VVHRDLKPSNILYVDE..........SGNP.....ECLRICDFGFAKQLRAENG..................LLMTPCYTANFVAPEVL..........KR...QGY.DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRI..........GS........GKFTLSGGNWNTV....................................SETAKDLVSKMLHVDPHQRLT.....AKQVLQHPWI #=GR KS6A1_MOUSE/407-664 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR KS6A1_MOUSE/407-664 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... PHKG2_RAT/24-291 YDPKDIIGRGVSSVV..RRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVA..GHPHIITLIDSYES.............SSFMF..LVFDLMRKGE....LFDYLT.......EKVA.LSEK.......ETR.SIMRSLLEAVNFLH.VNN...IVHRDLKPENILLD............DNM.......QIRLSDFGFSCHLEPGEK...................LRELCGTPGYLAPEILKCS....MDETH...PGY.GKEVDLWACGVILFTLLAGSPPFW..........HRRQ..ILMLRMIME.........GQYQFSSPEWDDR....................................SNTVKDLIAKLLQVDPNARLT.....AEQALQHPFF #=GR PHKG2_RAT/24-291 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR PHKG2_RAT/24-291 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... KCC4_MOUSE/42-296 FEVESELGRGATSIV..YRCKQKGTQKPYALKVLKKTVDK..........KIVRTEIGVLLRLS...HPNIIKLKEIFET.............PTEIS..LVLELVTGGE....LFDRIV.......EKGY.YSER.......DAR.DAVKQILEAVAYLH.ENG...IVHRDLKPENLLYA............TPAPD....APLKIADFGLSKIVEHQVL...................MKTVCGTPGYCAPEIL..........RG...CAY.GPEVDMWSVGIITYILLCGFEPFYDERGD...........QFMFRRILN.........CEYYFISPWWDEV....................................SLNAKDLVKKLIVLDPKKRLT.....TFQALQHPWV #=GR KCC4_MOUSE/42-296 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR KCC4_MOUSE/42-296 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... MYLK_CHICK/1453-1708 YNIEERLGSGKFGQV..FRLVEKKTGKVWAGKFFKAYSAKEKEN........IRDEISIMNCLH...HPKLVQCVDAFEE.............KANIV..MVLEMVSGGE....LFERII.......DEDFELTER.......ECI.KYMRQISEGVEYIH.KQG...IVHLDLKPENIMCVNK..........TGT.......SIKLIDFGLARRLESAGS...................LKVLFGTPEFVAPEVI..........NY...EPI.GYETDMWSIGVICYILVSGLSPFMGDNDNETLANVTSA.....................TWDFDDEAFDEI....................................SDDAKDFISNLLKKDMKSRLN.....CTQCLQHPWL #=GR MYLK_CHICK/1453-1708 AS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... #=GR MYLK_CHICK/1453-1708 pAS .................................................................................................................................................................................................................*................................................................................................................................................................................................................. CDPK_SOYBN/34-292 YEVGRKLGQGQFGTT..FECTRRASGGKFACKSIPKRKLLCKED.....YEDVWREIQIMHHLS..EHANVVRIEGTYED.............STAVH..LVMELCEGGE....LFDRIV.......QKGH.YSER.......QAA.RLIKTIVEVVEACH.SLG...VMHRDLKPENFLFD............TIDED....AKLKATDFGLSVFYKPGES...................FCDVVGSPYYVAPEVL...............RKLYGPESDVWSAGVILYILLSGVPPFWAESEPGIFRQILLG.....................KLDFHSEPWPSI....................................SDSAKDLIRKMLDQNPKTRLT.....AHEVLRHPWI #=GR CDPK_SOYBN/34-292 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR CDPK_SOYBN/34-292 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... Q8I534_PLAF7/111-364 YVLNKKIGKGSFSTA..YIGTNILYGNRVVVKEVDKSKVKE.........SNVYTEIEVLRKVM...HKYIIKLISAYEQ.............EGFVY..LVLEYLKGGE....LFEYLN.......NNGP.YTEQ.......VAK.KAMKRVLIALEALH.SNG...VVHRDLKMENLMLE............NPNDP....SSLKIIDFGLASFLNSPS....................MNMRCGSPGYVAPEIL..........KC...ASY.GTKVDIFSLGVILFNILCGYPPFRGNNVKEIFKKNMRC.....................HISFNTKHWINK....................................SESVKEIILWMCCKNPDDRCT.....ALQALGHQWF #=GR Q8I534_PLAF7/111-364 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. CHK1_SCHPO/10-272 YHIGREIGTGAFASV..RLCY.DDNAKIYAVKFVNKKHATSCMNAG.VWARRMASEIQLHKLCN..GHKNIIHFYNTAEN.............PQWRW..VVLEFAQGGD....LFDKIE.......PDVG.IDED.......VAQ.FYFAQLMEGISFMH.SKG...VAHRDLKPENILLD.Y..........NGN........LKISDFGFASLFSYKGKS................RLLNSPVGSPPYAAPEIT...............QQYDGSKVDVWSCGIILFALLLGNTPWD....................EAISNTGDYLLYKKQCERPSYHPWNLL....................................SPGAYSIITGMLRSDPFKRYS.....VKHVVQHPWL #=GR CHK1_SCHPO/10-272 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR CHK1_SCHPO/10-272 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... FUSED_DROME/4-254 YAVSSLVGQGSFGCV..YKATRKDDSKVVAIKVISKRGRATKEL......KNLRRECDIQARLK...HPHVIEMIESFES.............KTDLF..VVTEFALMD.....LHRYLS.......YNGA.MGEE.......PAR.RVTGHLVSALYYLH.SNR...ILHRDLKPQNVLLD............KNM.......HAKLCDFGLARNMTLGTH..................VLTSIKGTPLYMAPELL..........AE...QPY.DHHADMWSLGCIAYESMAGQPPFCASSILHLVKMIKHE.........................DVKWPSTL....................................TSECRSFLQGLLEKDPGLRIS.....WTQLLCHPFV #=GR FUSED_DROME/4-254 pAS ...........................................................................................................................................................................*.....................................*................................................................................................................................................................................................................. #=GR FUSED_DROME/4-254 sAS ............................................................................................................................................................................*...................................................................................................................................................................................................................................................... #=GC SS_cons EEEEEEEEEESSEEE..EEEEETTTTEEEEEEEEEHHCCCHHHHCT..THHHHHHHHHHHHHHSSSSSTTB--EEEEEEE.............SSEEE..EEEE--TTEB...EHHHHHHHS...SHHHSS.--HH.......HHH.HHHHHHHHHHHHHHHHTTSS.EE-SS-SGGGEEEETT..........TTECG..SSTEEEE-SGTTSEECCSSCSS..................BCTCCSCGGGS-HHHHHTTT-----TTT---STCTSHHHHHHHHHHHHHHHHHSS-STTTSSCHHHHHHHHHTT-HHHHHHHCT..........SHH......TTSTCCHHHHHHT.GGGTT.......SS...HHHH.TTS-HHHHHHHHHHT-SSGCCSTTTSTTTHHHHHTSGGG #=GC seq_cons aphhpplGpGsaGsV..apshptssschhAlKtlpppphpptp.......pthhpElpllpplp...HssIlplhssaps.............pspla..llhEaspsup....Lhchlp.......ppth.hsEp.......ps+.phhtpllpulcYlH.sps...llHRDlKPpNILlc.t..........pup........lKlsDFGlAphhssss....................hsshsGT.hYhAPEll..........ps...psY.uttsDlWSlGlllh-llsGpsPFt...spt.....hpp.........................t....ppl....................................SppspcllpphLphDPpcRho.....sppllpHsah //