MaximumLikelihoodDistanceEstimationMafIterator.h

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//
// File: MaximumLikelihoodDistanceEstimationMafIterators.h
// Created by: Julien Dutheil
// Created on: Nov 13 2012
//

/*
Copyright or © or Copr. Bio++ Development Team

This software is a computer program whose purpose is to test the
homogeneity of the substitution process of a given alignment.

This software is governed by the CeCILL  license under French law and
abiding by the rules of distribution of free software.  You can  use, 
modify and/ or redistribute the software under the terms of the CeCILL
license as circulated by CEA, CNRS and INRIA at the following URL
"http://www.cecill.info". 

As a counterpart to the access to the source code and  rights to copy,
modify and redistribute granted by the license, users are provided only
with a limited warranty  and the software's author,  the holder of the
economic rights,  and the successive licensors  have only  limited
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In this respect, the user's attention is drawn to the risks associated
with loading,  using,  modifying and/or developing or reproducing the
software by the user in light of its specific status of free software,
that may mean  that it is complicated to manipulate,  and  that  also
therefore means  that it is reserved for developers  and  experienced
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*/

#ifndef _MAXIMUMLIKELIHOODDISTANCEESTIMATIONMAFITERATOR_H_
#define _MAXIMUMLIKELIHOODDISTANCEESTIMATIONMAFITERATOR_H_

#include "AbstractDistanceEstimationMafIterator.h"

//From bpp-phyl:
#include <Bpp/Phyl/OptimizationTools.h>

namespace bpp {

class MaximumLikelihoodDistanceEstimationMafIterator:
  public AbstractDistanceEstimationMafIterator
{
  private:
    std::auto_ptr<DistanceEstimation> distEst_;
    double propGapsToKeep_; //Exclude sites with too many gaps
    bool gapsAsUnresolved_;  //For most models, should be yes as they do not allow for gap characters
    std::string paramOpt_;

  public:
    MaximumLikelihoodDistanceEstimationMafIterator(MafIterator* iterator,
        DistanceEstimation* distEst,
        double propGapsToKeep = 0,
        bool gapsAsUnresolved = true,
        const string& paramOpt = OptimizationTools::DISTANCEMETHOD_INIT,
        bool verbose = true):
      AbstractDistanceEstimationMafIterator(iterator),
      distEst_(distEst), propGapsToKeep_(propGapsToKeep), gapsAsUnresolved_(gapsAsUnresolved), paramOpt_(paramOpt)
    {
      setVerbose(verbose);
      distEst_->setVerbose(verbose ? 3 : 0);
    }

  private:
    MaximumLikelihoodDistanceEstimationMafIterator(const MaximumLikelihoodDistanceEstimationMafIterator& iterator):
      AbstractDistanceEstimationMafIterator(0),
      distEst_(0), propGapsToKeep_(iterator.propGapsToKeep_),
      gapsAsUnresolved_(iterator.gapsAsUnresolved_), paramOpt_(iterator.paramOpt_)
    {}
    
    MaximumLikelihoodDistanceEstimationMafIterator& operator=(const MaximumLikelihoodDistanceEstimationMafIterator& iterator)
    {
      distEst_.reset();
      propGapsToKeep_ = iterator.propGapsToKeep_;
      gapsAsUnresolved_ = iterator.gapsAsUnresolved_;
      paramOpt_ = iterator.paramOpt_;
      return *this;
    }
      
  public:
    std::string getPropertyName() const { return "MLDistance"; }
    DistanceMatrix* estimateDistanceMatrixForBlock(const MafBlock& block);

};

} //end of namespace bpp.

#endif //_MAXIMUMLIKELIHOODDISTANCEESTIMATIONMAFITERATOR_H_